Wound Healing

During the last few decades the interest in development of controlled drug delivery approaches has been growing constantly. The increasing resistance of microorganisms against antibiotics in the treatment of wounds has led to the renaissance of antiseptic drugs for local application in the treatment of wound infections. CaptiGel encapsulated drugs have the potential to become clinically valuable in human and veterinary medicine in wound dressings and sprays.

  • Wound dressings

    The unique absorptive and controlled release characteristics of CaptiGel in combination with its capacity to chemical degradation and biodigestion in inflamed tissue, makes it an attractive choice for wound dressings. Experiments have shown that the titanium oxide particles containing the encapsulated drug can be chemically grafted onto a fabric of nanocellulose material, which will lead to a very stable product.

  • Sprays

    Sprays containing antiseptic drugs could be convenient alternatives for treatment of severe wounds. Controlled release of the drug can be achieved by covering the drug with the unique titanium dioxide particles.

Less antibiotics needed when locally distributed

Up to 86% of the patients who come to the skin clinic with leg ulcers has been reported to be on antibiotics or have received antibiotics during the last six months period. The results of the national quality register for slow-healing wounds (RiksSår) shows that it is possible to reduce the frequency of antibiotic treatment considerably through the use of alternative treatments. An adequate use of local antiseptics plays an important role in this case.

Local administration of drugs will lead to a decrease of the release of non-destructed drugs into wastewaters, inevitable otherwise in per-oral ordination and furthermore decreased systemic impact on the patient.

A more efficient system for controlled release

The CaptiGel technology is of highest interest for topical treatment of patients with severe wounds. There is a need for more effective system for controlled release of the active ingredients in units that have an active healing function like wound plasters, sprays and other wound protection utilities. The advantage with the CapriGel technology is based on the chemical binding of the active substances to the nanoparticles, which makes it possible to control the release of the active substance. Furthermore the particles will be actively degraded after the release of the encapsulated substance.

The key is that the method is based on chemical binding instead of physical adsorption.

drug-release

The drug release profile of tetracycline with and without CaptiGel as a binding agent.  In case (a) tetracycline is enclosed in CaptiGel, which is chemically grafted onto the nano cellulose carrier material, whereas in case (b) tetracycline is only physically absorbed onto the cellulose nano fiber surface. (Reference: J of Mater Chem B, 2015,3, 7125).