Technology

The CaptiGel technology allows for a cost-efficient production of biocompatible particles for encapsulation. The nanoparticles in the form of a titanium dioxide based sol-gel gather around the selected material or molecules to form a hard, protective shell, resistant to both UV light and harsh chemicals.

An innovation based on nanoparticles

The CaptiGel technology is based on the finding that nanoparticles of metal oxides (e.g. titanium dioxide) produced in an organic environment can be transferred to a water-based environment without forming precipitates. This is possible as they are equipped with a hydrophilic ligand. This new discovery is the basis for the utility of the unique CaptiGel biocompatible particles for encapsulation of biological material. Materials like molecules, viruses, bacteria, seeds, plant tissues, nutrients, enzymes, peptides and bioactive substances can be encapsulated.

How is the release of encapsulated material controlled?

The titanium dioxide is biodegradable and the release of the encapsulated substances can be triggered both chemically in the presence of polycarbonates and bio-chemically for example by bacteria.

 The possibility of a controlled chemical release gives CaptiGel an advantage versus silica-based nanoparticles and makes CaptiGel well suited for applications in for example wound healing.

Environmentally friendly UV resistance

The methods used today for UV protection are either crystallin titanium oxide or the  substance Benzofenon-3 (BP-3; oxybenzon). Because of the unwanted production of free radicals by the titanium oxide the cosmetic industry has increasingly moved to using Benzophenon-3 instead. However, this substance has now become an increasing pollution problem in marine environments. Both problems can be avoided by using the CaptiGel product with an amorphous outer shell, which absorbs the free radicals.

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Positively charged micelles are attracted to the negatively charged cell membrane surface and encapsulated it in a continuous shell with UV-protective properties. The shell is biodegradable and the encapsulated material can be released with chemical or bio-chemical triggers.